RT Journal Article
SR Electronic
T1 On the Mechanism of Oxidative Cleavage of Aryl-Alkyl Ethers by Liver Microsomes
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 145
OP 148
VO 1
IS 2
A1 JEAN RENSON
A1 HERBERT WEISSBACH
A1 SIDNEY UDENFRIEND
YR 1965
UL http://molpharm.aspetjournals.org/content/1/2/145.abstract
AB Studies with 18O2 and H218O have shown that oxidative O-demethylation of p-methoxyacetanilide by liver microsomes involves the cleavage of the oxygen methyl bond with no incorporation of oxygen into the phenolic product. They indicate that the intact methoxy group is not displaced by a hydroxyl group. Furthermore, p-methoxyphenylalanine was not converted to tyrosine by liver phenylalanine hydroxylase. These findings indicate that the microsomal cleavage of aryl-alkyl ethers is not catalyzed by an aromatic hydroxylase.