PT  - JOURNAL ARTICLE
AU  - WACLAW SZYBALSKI
AU  - V. G. ARNESON
TI  - Reductive Activation and Inactivation of Mitomycin As Studied with Human and Bacterial Cell Cultures
DP  - 1965 Sep 01
TA  - Molecular Pharmacology
PG  - 202--204
VI  - 1
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/1/2/202.short
4100  - http://molpharm.aspetjournals.org/content/1/2/202.full
SO  - Mol Pharmacol1965 Sep 01; 1
AB  - Sodium borohydride at noninhibitory concentrations (50 µg/ml) reverses almost completely the lethal effects of mitomycin C when added within 5 min (human cell cultures) or 10 sec (bacteria) after cell exposure to the antibiotic. Sodium cyanide, dinitrophenol, and phenethyl alcohol, shown previously to augment the bactericidal effects of mitomycin, have no influence on the lethal action of this antibiotic for human cells. ACKNOWLEDGMENTS We are indebted to Dr. S. Wakaki (Kyowa Hakko Kogyo Co., Tokyo) for supplying us with mitomycin C, and to Dr. Elizabeth H. Szybalska for her editorial help. This study was supported by Grant CA-07175 from the National Cancer Institute.