PT  - JOURNAL ARTICLE
AU  - NORMAN D. HINMAN
AU  - JOHN R. CANN
TI  - Reversible Binding of Chlorpromazine to Brain Tubulin
DP  - 1976 Sep 01
TA  - Molecular Pharmacology
PG  - 769--777
VI  - 12
IP  - 5
4099  - http://molpharm.aspetjournals.org/content/12/5/769.short
4100  - http://molpharm.aspetjournals.org/content/12/5/769.full
SO  - Mol Pharmacol1976 Sep 01; 12
AB  - Chlorpromazine binds reversibly to brain tubulin via two well-resolved processes. One chlorpromazine molecule binds strongly compared with 8-9 molecules that bind weakly. Binding to the higher-affinity site is chiefly entropy-driven, implicating hydrophobic forces. The two binding processes are compared with the biological activities of chlorpromazine in vitro. ACKNOWLEDGMENT The authors thank Mr. Robert O. Coombs for technical assistance.