RT Journal Article
SR Electronic
T1 Reversible Binding of Chlorpromazine to Brain Tubulin
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 769
OP 777
VO 12
IS 5
A1 HINMAN, NORMAN D.
A1 CANN, JOHN R.
YR 1976
UL http://molpharm.aspetjournals.org/content/12/5/769.abstract
AB Chlorpromazine binds reversibly to brain tubulin via two well-resolved processes. One chlorpromazine molecule binds strongly compared with 8-9 molecules that bind weakly. Binding to the higher-affinity site is chiefly entropy-driven, implicating hydrophobic forces. The two binding processes are compared with the biological activities of chlorpromazine in vitro. ACKNOWLEDGMENT The authors thank Mr. Robert O. Coombs for technical assistance.