PT  - JOURNAL ARTICLE
AU  - K. FICKENTSCHER
AU  - A. KIRFEL
AU  - G. WILL
AU  - F. KÖHLER
TI  - Stereochemical Properties and Teratogenic Activity of Some Tetrahydrophthalimides
DP  - 1977 Jan 01
TA  - Molecular Pharmacology
PG  - 133--141
VI  - 13
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/13/1/133.short
4100  - http://molpharm.aspetjournals.org/content/13/1/133.full
SO  - Mol Pharmacol1977 Jan 01; 13
AB  - The embryotoxic and teratogenic activities of three thalidomide analogues containing nonplanar tetrahydrophthalimide moieties, of the corresponding three imides, and of their N-methyl derivatives were tested in SWS mice. The molecular structures of three imides were established simultaneously by X-ray diffraction analysis. One of the three nonplanar thalidomide analogues is teratogenic and therefore does not support the intercalation hypothesis of the thalidomide action. The tendency of the three sulfur-containing compounds for complex formation is discussed.