RT Journal Article
SR Electronic
T1 Inhibition of Sodium- and Potassium-Dependent Adenosine Triphosphatase by Serotonin
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 181
OP 184
VO 13
IS 1
A1 SIXTO GARCÍA-CASTINEIRAS
A1 JOHN I. WHITE
A1 EFRAÍN TORO-GOYCO
YR 1977
UL http://molpharm.aspetjournals.org/content/13/1/181.abstract
AB Serotonin was identified as the potent (Na+ + K+-ATPase inhibitor previously reported to be present in the coelenterate Palythoa caribaeorum. As the serotonin-creatinine sulfate complex (commercial preparations) its inhibitory potency is sharply reduced. Inhibition is fully restored on fractionation of the complex on cation-exchange resins. ACKNOWLEDGMENTS We thank Professor J. del Castillo and Mr. F. McKenzie for their generous supply of E. electricus and P. caribaeorum.