@article {LEIBMAN239, author = {KENNETH C. LEIBMAN}, title = {Metabolism of Trichloroethylene in Liver Microsomes}, volume = {1}, number = {3}, pages = {239--246}, year = {1965}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The conversion of trichloroethylene to chloral hydrate was shown to take place in liver microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates in Tris buffer was used, from which a fraction could be obtained which resembled fresh microsomes in behavior. The effects of a number of activators and inhibitors of the enzyme system are described. ACKNOWLEDGMENTS It is a pleasure to acknowledge the excellent technical assistance of Miss Elsa Ortiz. This work was supported in part by U.S. Public Health Service Research Grant No. OH-00124.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/1/3/239}, eprint = {https://molpharm.aspetjournals.org/content/1/3/239.full.pdf}, journal = {Molecular Pharmacology} }