PT  - JOURNAL ARTICLE
AU  - LEIBMAN, KENNETH C.
TI  - Metabolism of Trichloroethylene in Liver Microsomes
DP  - 1965 Nov 01
TA  - Molecular Pharmacology
PG  - 239--246
VI  - 1
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/1/3/239.short
4100  - http://molpharm.aspetjournals.org/content/1/3/239.full
SO  - Mol Pharmacol1965 Nov 01; 1
AB  - The conversion of trichloroethylene to chloral hydrate was shown to take place in liver microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates in Tris buffer was used, from which a fraction could be obtained which resembled fresh microsomes in behavior. The effects of a number of activators and inhibitors of the enzyme system are described. ACKNOWLEDGMENTS It is a pleasure to acknowledge the excellent technical assistance of Miss Elsa Ortiz. This work was supported in part by U.S. Public Health Service Research Grant No. OH-00124.