@article {HUSZAR1086, author = {LESLIE A. HUSZAR and JEFFREY H. GREENBERG and ALAN MELLORS}, title = {Effects of Δ9-Tetrahydrocannabinol on Lymphocyte and Synaptosomal Lysophosphatidylcholine Acyltransferases in Vivo}, volume = {13}, number = {6}, pages = {1086--1091}, year = {1977}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Δ9-Tetrahydrocannabinol was administered to mice intravenously at 15-70 mg/kg. Two hours later the effect of the drug in vivo on brain synaptosomes and spleen lymphocytes was determined. Inhibition of acyl-CoA-lysophosphatidylcholine acyltransferase was significant in the synaptosome (maximum inhibition, 44\%) and lymphocyte preparations (maximum inhibition, 24\%). In lymphocytes there was concomitant inhibition of blastogenesis as measured by [3H]thymidine incorporation. ACKNOWLEDGMENT The authors thank Health and Welfare Canada for the gift of cannabinoids.}, issn = {0026-895X}, URL = {https://molpharm.aspetjournals.org/content/13/6/1086}, eprint = {https://molpharm.aspetjournals.org/content/13/6/1086.full.pdf}, journal = {Molecular Pharmacology} }