RT Journal Article
SR Electronic
T1 The Inhibitory Effect of Aurintricarboxylic Acid on the Attachment of Ribosomes to Microsomal Membranes <em>in Vitro</em>
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 220
OP 224
VO 14
IS 1
A1 ELENA BUSSOLATI
A1 RENATA BIDOGLIA
A1 NICA BORGESE
YR 1978
UL http://molpharm.aspetjournals.org/content/14/1/220.abstract
AB Aurintricarboxylic acid was shown to inhibit the binding of ribosomes to rough microsomal membranes stripped of their ribosomes in a cell-free system derived from rat liver. The ED50 was equal to 65 µM. The inhibitory effect was due to the binding of aurintricarboxylic acid to some membrane component necessary for the attachment of ribosomes. 1-Anilinonaphthalene-8-sulfonic acid also inhibited ribosome binding, but higher concentrations of the drug were necessary. ACKNOWLEDGMENT We thank Dr. Jacopo Meldolesi for helpful discussions.