TY - JOUR T1 - Inhibition of the Phosphorylation of Nonhistone Chromosomal Proteins by Cordycepin and Xylosyladenine in L1210 Cells <em>in Vitro</em> JF - Molecular Pharmacology JO - Mol Pharmacol SP - 1130 LP - 1135 VL - 14 IS - 6 AU - MICHEL LEGRAVEREND AU - ROBERT I. GLAZER Y1 - 1978/11/01 UR - http://molpharm.aspetjournals.org/content/14/6/1130.abstract N2 - Cordycepin and xylosyladenine were tested for their inhibitory effect upon the phosphorylation of nuclear proteins in L1210 cells in vitro. As indicated by isoelectric focusing of urea-soluble nuclear proteins, the phosphorylation of acidic nonhistone chromosomal proteins was strongly inhibited by both nucleosides, particularly in the presence of the adenosine deaminase inhibitor, 2'-deoxycoformycin. These observations may explain, in part, the inhibitory effect of both drugs upon transcription. ER -