RT Journal Article SR Electronic T1 Rat Hepatic Nuclear Cytochrome P-450 and Epoxide Hydrase in Membranes Prepared by Two Methods: Similarities with the Microsomal Enzymes JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 192 OP 196 VO 15 IS 1 A1 HASAN MUKHTAR A1 TAHANI H. ELMAMLOUK A1 RICHARD M. PHILPOT A1 JOHN R. BEND YR 1979 UL http://molpharm.aspetjournals.org/content/15/1/192.abstract AB Cytochrome P-450 in rat liver nuclear membranes of untreated, PB-pretreated, or 3-MC-pretreated animals was spectrally similar to corresponding liver microsomes. Epoxide hydrase activity of liver nuclear membrane and microsomes was induced by PB administration; 3-MC did not cause any induction. The same results were obtained when either the DNase digestion method or sucrose density centrifugation technique for preparation of nuclear membranes was used.