TY - JOUR T1 - Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity JF - Molecular Pharmacology JO - Mol Pharmacol SP - 151 LP - 156 VL - 18 IS - 1 AU - SUZANNE E. PATTON AU - GERALD M. ROSEN AU - ELMER J. RAUCKMAN AU - DOYLE G. GRAHAM AU - BARBARA SMALL AU - DANIEL M. ZIEGLER Y1 - 1980/07/01 UR - http://molpharm.aspetjournals.org/content/18/1/151.abstract N2 - Nuclei isolated from hamster liver contain activities characteristic of the mixed-function amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase, catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram protein of isolated nuclei is 12-14% that of microsomes. The hamster liver monooxygenase cross-reacts with antibodies raised in rabbits to the homogeneous pig liver microsomal mixed-function amine oxidase, and isolated nuclei stained with fluorescent labeled anti-body indicate that the monooxygenase is largely concentrated in the nuclear envelope. ER -