PT - JOURNAL ARTICLE AU - SUZANNE E. PATTON AU - GERALD M. ROSEN AU - ELMER J. RAUCKMAN AU - DOYLE G. GRAHAM AU - BARBARA SMALL AU - DANIEL M. ZIEGLER TI - Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity DP - 1980 Jul 01 TA - Molecular Pharmacology PG - 151--156 VI - 18 IP - 1 4099 - http://molpharm.aspetjournals.org/content/18/1/151.short 4100 - http://molpharm.aspetjournals.org/content/18/1/151.full SO - Mol Pharmacol1980 Jul 01; 18 AB - Nuclei isolated from hamster liver contain activities characteristic of the mixed-function amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase, catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram protein of isolated nuclei is 12-14% that of microsomes. The hamster liver monooxygenase cross-reacts with antibodies raised in rabbits to the homogeneous pig liver microsomal mixed-function amine oxidase, and isolated nuclei stained with fluorescent labeled anti-body indicate that the monooxygenase is largely concentrated in the nuclear envelope.