RT Journal Article
SR Electronic
T1 Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Location and Specific Activity
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 151
OP 156
VO 18
IS 1
A1 SUZANNE E. PATTON
A1 GERALD M. ROSEN
A1 ELMER J. RAUCKMAN
A1 DOYLE G. GRAHAM
A1 BARBARA SMALL
A1 DANIEL M. ZIEGLER
YR 1980
UL http://molpharm.aspetjournals.org/content/18/1/151.abstract
AB Nuclei isolated from hamster liver contain activities characteristic of the mixed-function amine oxidase. The enzyme present in nuclei, like the microsomal monooxygenase, catalyzes the oxygenation of both nitrogen and sulfur compound. Activity per milligram protein of isolated nuclei is 12-14% that of microsomes. The hamster liver monooxygenase cross-reacts with antibodies raised in rabbits to the homogeneous pig liver microsomal mixed-function amine oxidase, and isolated nuclei stained with fluorescent labeled anti-body indicate that the monooxygenase is largely concentrated in the nuclear envelope.