PT  - JOURNAL ARTICLE
AU  - SHERYL BALDWIN
AU  - LEMONT B. KIER
AU  - DONALD SHILLADY
TI  - Approximate Molecular Potentials of Mescaline Analogues in a Study of Similarities to 5-Hydroxytryptamine
DP  - 1980 Nov 01
TA  - Molecular Pharmacology
PG  - 455--460
VI  - 18
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/18/3/455.short
4100  - http://molpharm.aspetjournals.org/content/18/3/455.full
SO  - Mol Pharmacol1980 Nov 01; 18
AB  - The electrostatic potentials of five substituted phenethylamines have been calculated and compared with that of 5-hydroxytryptamine (5-HT). A common pattern of potentials was found in four of the five phenethylamines and 5-hydroxytryptamine which is associated with a previously postulated 5-HT pharmacophore. These four analogues are qualitatively reported as being hallucinogenic; the fifth analogue is not. A quantitative relationship was found between the hallucinogenic potency in the four phenethylamines and the decline of a negative electrostatic potential in the region between the 3 and 4 phenyl positions, reinforcing previous reports on the quantitative importance of this part of the molecule.