RT Journal Article
SR Electronic
T1 Approximate Molecular Potentials of Mescaline Analogues in a Study of Similarities to 5-Hydroxytryptamine
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 455
OP 460
VO 18
IS 3
A1 BALDWIN, SHERYL
A1 KIER, LEMONT B.
A1 SHILLADY, DONALD
YR 1980
UL http://molpharm.aspetjournals.org/content/18/3/455.abstract
AB The electrostatic potentials of five substituted phenethylamines have been calculated and compared with that of 5-hydroxytryptamine (5-HT). A common pattern of potentials was found in four of the five phenethylamines and 5-hydroxytryptamine which is associated with a previously postulated 5-HT pharmacophore. These four analogues are qualitatively reported as being hallucinogenic; the fifth analogue is not. A quantitative relationship was found between the hallucinogenic potency in the four phenethylamines and the decline of a negative electrostatic potential in the region between the 3 and 4 phenyl positions, reinforcing previous reports on the quantitative importance of this part of the molecule.