RT Journal Article
SR Electronic
T1 Nucleolar Cytochrome <em>P</em>-450
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 550
OP 552
VO 18
IS 3
A1 BRESNICK, EDWARD
A1 HASSUK, BRUCE
A1 LIBERATOR, PAUL
A1 LEVIN, WAYNE
A1 THOMAS, PAUL E.
YR 1980
UL http://molpharm.aspetjournals.org/content/18/3/550.abstract
AB Significant amounts of cytochrome P-450 have been detected spectrally in purified nucleoli obtained from the livers of 3-methylcholanthrene-treated rats. Using monospecific antibody to microsomal cytochrome P-450c (P-448), we have shown that the nucleolar and microsomal enzymes are immunochemically identical. These nucleoli also contained epoxide hydrolase and NADPH-cytochrome c reductase activities, both of which were immunochemically identical to their respective microsomal counterparts.