RT Journal Article SR Electronic T1 Studies of the Porphyrin-Inducing Activity of Ethynyl Compounds and Conformationally Restricted and Unrestricted Analogues of Allylisopropylacetamide in Chick Embryo Liver Cell Culture JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 206 OP 210 VO 20 IS 1 A1 GERALD S. MARKS A1 STEPHEN B. ZIMMER A1 STEPHEN E. DINIZO A1 BRUCE A. MICO A1 KENT L. KUNZE A1 PAUL R. ORTIZ DE MONTELLANO YR 1981 UL http://molpharm.aspetjournals.org/content/20/1/206.abstract AB A series of conformationally restricted and unrestricted analogues of allylisopropylacetamide (AIA) and a group of ethynyl compounds have been tested for porphyrin-inducing activity in chick embryo liver cell culture. The conformationally restricted analogues, which do not share the ability of AIA to destroy rat and chick embryo hepatic cytochrome P-450, were nevertheless shown to induce porphyrin accumulation. The conformationally unrestricted analogues and the ethynyl compounds which do share the ability of AIA to destroy rat hepatic cytochrome P-450 possessed weak to moderate porphyrin-inducing activity or were inactive. It is concluded that in chick embryo liver cell culture, in contrast to the situation in rat liver, destruction of the heme moiety of cytochrome P-450 does not appear to be a prerequisite for δ-aminolevulinic acid synthetase induction and porphyrin accumulation.