RT Journal Article
SR Electronic
T1 The Effect of Alprenolol on the <em>Beta</em>-Receptor and Adenylate Cyclase Activity in Rabbit Heart Membranes
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 224
OP 226
VO 20
IS 1
A1 V. A. TKACHUK
A1 M. WOLLEMANN
YR 1981
UL http://molpharm.aspetjournals.org/content/20/1/224.abstract
AB Incubation of rabbit heart membranes at 37° with 10-5 M alprenolol significantly increased the number of beta-receptor binding sites but did not change the adenylate cyclase activity. In the presence of guanine nucleotides, the effect of alprenolol incubation on the beta-receptor was enhanced. When the incubation was carried out at 4°, the alprenolol effect was lost.