PT  - JOURNAL ARTICLE
AU  - TIZIANA MENNINI
AU  - ELENA POGGESI
AU  - SUSANNA COTECCHIA
AU  - ANTONIO DE BLASI
AU  - ROSARIO SAMANIN
TI  - Changes in Serotonin, but Not Catecholamine, Receptor Binding in the Brain of Morphine-Dependent Rats
DP  - 1981 Sep 01
TA  - Molecular Pharmacology
PG  - 237--239
VI  - 20
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/20/2/237.short
4100  - http://molpharm.aspetjournals.org/content/20/2/237.full
SO  - Mol Pharmacol1981 Sep 01; 20
AB  - Chronic morphine administration causes a 40% reduction of 3H-labeled 5-hydroxytryptamine (5-HT) binding in the brain stems of dependent rats, with little or no effect in other brain regions. Binding of [3H]dihydroalprenolol, 2,2,6-[3H]dimethoxyphenoxy-(ethylaminomethyl)benzodioxan, and [3H]spiroperidol is not affected by this treatment. The specificity of the reduction in 5-HT receptor number in the brain stem is discussed in terms of persistent activation of central 5-HT neurons by long-term treatment with morphine.