PT  - JOURNAL ARTICLE
AU  - ROZE, ULDIS
AU  - STROMINGER, JACK L.
TI  - Alanine Racemase from <em>Staphylococcus aureus:</em> Conformation of Its Substrates and Its Inhibitor, D-Cycloserine
DP  - 1966 Feb 01
TA  - Molecular Pharmacology
PG  - 92--94
VI  - 2
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/2/1/92.short
4100  - http://molpharm.aspetjournals.org/content/2/1/92.full
SO  - Mol Pharmacol1966 Feb 01; 2
AB  - D-Cycloserine is a competitive inhibitor of alanine racemase for which its Ki is 100 times smaller than the Km for either of the substrates, D- and L-alanine. L-Cycloserine, however, does not inhibit this enzyme. A hypothesis is proposed, based on molecular models, that D-cycloserine has the conformation required of the substrates on the enzyme surface. L-Cycloserine cannot have this conformation.