PT  - JOURNAL ARTICLE
AU  - H. REMMER
AU  - J. SCHENKMAN
AU  - R. W. ESTABROOK
AU  - H. SASAME
AU  - J. GILLETTE
AU  - S. NARASIMHULU
AU  - D. Y. COOPER
AU  - O. ROSENTHAL
TI  - Drug Interaction with Hepatic Microsomal Cytochrome
DP  - 1966 Apr 01
TA  - Molecular Pharmacology
PG  - 187--190
VI  - 2
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/2/2/187.short
4100  - http://molpharm.aspetjournals.org/content/2/2/187.full
SO  - Mol Pharmacol1966 Apr 01; 2
AB  - The addition to liver microsomes of various substrates, such as hexobarbital, aminopyrine, or aniline, causes two types of spectral changes. Spectrophotometric studies suggest that these changes are related to substrate interaction with a microsomal hemoprotein. On the basis of these observations, two hypotheses are suggested to explain the interaction of substrates with the liver microsomal mixed function oxidase system. This work was supported in part by a grant from the National Science Foundation (GB 2451) and grants (AM 07217, AM 04484, and GM 12202) of the U. S. Public Health Service. The studies were carried out during tenures of U.S.P.H.S. Research Career Development Awards HE 25132 to D. Y. Cooper and GM-K3-4111 to R. W. Estabrook.