PT  - JOURNAL ARTICLE
AU  - W G Harrelson, Jr
AU  - R P Mason
TI  - Microsomal reduction of gentian violet. Evidence for cytochrome P-450-catalyzed free radical formation.
DP  - 1982 Sep 01
TA  - Molecular Pharmacology
PG  - 239--242
VI  - 22
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/22/2/239.short
4100  - http://molpharm.aspetjournals.org/content/22/2/239.full
SO  - Mol Pharmacol1982 Sep 01; 22
AB  - The triarylmethane dye, gentian violet, is shown to undergo a one-electron reduction by the cytochrome P-450 monooxygenase system to produce a carbon-centered free radical as demonstrated by direct electron spin resonance techniques. The formation of this species is inhibited by carbon monoxide and metyrapone, suggesting the involvement of cytochrome P-450. Either NADPH or NADH can serve as a source of reducing equivalents for the production of this free radical. Related triarylmethane dyes are also shown to be reduced by the monooxygenase system to form free radicals.