PT  - JOURNAL ARTICLE
AU  - J G Liehr
TI  - 2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity.
DP  - 1983 Mar 01
TA  - Molecular Pharmacology
PG  - 278--281
VI  - 23
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/23/2/278.short
4100  - http://molpharm.aspetjournals.org/content/23/2/278.full
SO  - Mol Pharmacol1983 Mar 01; 23
AB  - Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4-Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself.