TY - JOUR T1 - 2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity. JF - Molecular Pharmacology JO - Mol Pharmacol SP - 278 LP - 281 VL - 23 IS - 2 AU - J G Liehr Y1 - 1983/03/01 UR - http://molpharm.aspetjournals.org/content/23/2/278.abstract N2 - Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4-Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself. ER -