RT Journal Article
SR Electronic
T1 2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity.
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 278
OP 281
VO 23
IS 2
A1 J G Liehr
YR 1983
UL http://molpharm.aspetjournals.org/content/23/2/278.abstract
AB Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4-Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself.