RT Journal Article SR Electronic T1 2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity. JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP 278 OP 281 VO 23 IS 2 A1 J G Liehr YR 1983 UL http://molpharm.aspetjournals.org/content/23/2/278.abstract AB Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4-Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself.