TY - JOUR T1 - Modification of the binding properties of muscarinic receptors by gallamine. JF - Molecular Pharmacology JO - Mol Pharmacol SP - 551 LP - 557 VL - 23 IS - 3 AU - J M Stockton AU - N J Birdsall AU - A S Burgen AU - E C Hulme Y1 - 1983/05/01 UR - http://molpharm.aspetjournals.org/content/23/3/551.abstract N2 - The interaction of gallamine with muscarinic receptors from different tissues has been investigated. Gallamine binds to a site distinct from the conventional muscarinic ligand binding site and modulates the binding of agonists and antagonists to the conventional binding site. In agreement with reported pharmacological studies, the effects of gallamine on the binding of muscarinic ligands are much greater in heart than in other tissues. These findings suggest the possibility of developing novel and selective muscarinic drugs. ER -