TY - JOUR T1 - Identification of 2-imidazolines as anti-sickling agents. JF - Molecular Pharmacology JO - Mol Pharmacol SP - 731 LP - 734 VL - 23 IS - 3 AU - H Chang AU - S M Ewert AU - R L Nagel Y1 - 1983/05/01 UR - http://molpharm.aspetjournals.org/content/23/3/731.abstract N2 - The drugs tolazoline, clonidine, lofexidine, and fenmetozole were found to inhibit the gelation of hemoglobin S in the order of increasing effectiveness. Only the latter, however, reduced the sickling of red cells significantly and normalized the oxygen affinity of SS blood at 5-10 mM concentrations. Since this level of drug is lower than those reported for many other anti-sickling agents to achieve comparable effects, the 2-imidazoline class of compounds may provide important clues for the development of therapy for sickle cell anemia. ER -