PT  - JOURNAL ARTICLE
AU  - R. P. MAICKEL
AU  - M. T. BUSH
AU  - W. R. JONDORF
AU  - F. P. MILLER
AU  - J. R. GILLETTE
TI  - Factors Influencing the Metabolism and Distribution of Corticosterone-1,2-<sup>3</sup>H in the Rat
DP  - 1966 Sep 01
TA  - Molecular Pharmacology
PG  - 491--495
VI  - 2
IP  - 5
4099  - http://molpharm.aspetjournals.org/content/2/5/491.short
4100  - http://molpharm.aspetjournals.org/content/2/5/491.full
SO  - Mol Pharmacol1966 Sep 01; 2
AB  - The metabolism and distribution of intravenously administered tracer doses of corticosterone-1,2-3H are not affected by elevated plasma levels of endogenous corticosterone due to cold stress. Pretreatment with methylcholanthrene increased the plasma half-life of the labeled steroid, reflecting a decreased rate of metabolic destruction, but had no effect on the apparent volume of distribution. Pretreatment with phenylbutazone caused an increased volume of distribution with no change in the plasma half-life.