RT Journal Article
SR Electronic
T1 Factors Influencing the Metabolism and Distribution of Corticosterone-1,2-<sup>3</sup>H in the Rat
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 491
OP 495
VO 2
IS 5
A1 R. P. MAICKEL
A1 M. T. BUSH
A1 W. R. JONDORF
A1 F. P. MILLER
A1 J. R. GILLETTE
YR 1966
UL http://molpharm.aspetjournals.org/content/2/5/491.abstract
AB The metabolism and distribution of intravenously administered tracer doses of corticosterone-1,2-3H are not affected by elevated plasma levels of endogenous corticosterone due to cold stress. Pretreatment with methylcholanthrene increased the plasma half-life of the labeled steroid, reflecting a decreased rate of metabolic destruction, but had no effect on the apparent volume of distribution. Pretreatment with phenylbutazone caused an increased volume of distribution with no change in the plasma half-life.