TY - JOUR T1 - Inhibition of erythrocyte sickling by thiol reagents. JF - Molecular Pharmacology JO - Mol Pharmacol SP - 559 LP - 565 VL - 26 IS - 3 AU - M C Garel AU - C Domenget AU - F Galacteros AU - J Martin-Caburi AU - Y Beuzard Y1 - 1984/11/01 UR - http://molpharm.aspetjournals.org/content/26/3/559.abstract N2 - The antisickling effects of eight thiol reagents that cross the red cell membrane and then react with the cysteine beta 93, the only accessible thiol group of hemoglobin, have been investigated at various pO2 values. In spite of completely reacted hemoglobins, the potent antisickling effect varied from one compound to the other and was partially related to the extent of the increased oxygen affinity of intact sickle cells induced by these compounds. The formation of methemoglobin upon the incubation of red blood cells with some disulfides had only a small effect on the sickling process. ER -