TY - JOUR T1 - Quantitative structure-activity relationships and molecular graphics in ligand receptor interactions: amidine inhibition of trypsin. JF - Molecular Pharmacology JO - Mol Pharmacol SP - 436 LP - 446 VL - 29 IS - 4 AU - M Recanatini AU - T Klein AU - C Z Yang AU - J McClarin AU - R Langridge AU - C Hansch Y1 - 1986/04/01 UR - http://molpharm.aspetjournals.org/content/29/4/436.abstract N2 - Quantitative structure-activity relationships have been formulated for four sets of amidine inhibitors of trypsin. The quantitative results from these equations are compared with qualitative models constructed from the X-ray crystallographic coordinates of a benzamidine bound to trypsin. The good agreement between the mathematical and graphics models provides further support for the use of substituent constants and regression analysis in the study of enzyme-ligand interactions. ER -