%0 Journal Article %A M Recanatini %A T Klein %A C Z Yang %A J McClarin %A R Langridge %A C Hansch %T Quantitative structure-activity relationships and molecular graphics in ligand receptor interactions: amidine inhibition of trypsin. %D 1986 %J Molecular Pharmacology %P 436-446 %V 29 %N 4 %X Quantitative structure-activity relationships have been formulated for four sets of amidine inhibitors of trypsin. The quantitative results from these equations are compared with qualitative models constructed from the X-ray crystallographic coordinates of a benzamidine bound to trypsin. The good agreement between the mathematical and graphics models provides further support for the use of substituent constants and regression analysis in the study of enzyme-ligand interactions. %U https://molpharm.aspetjournals.org/content/molpharm/29/4/436.full.pdf