PT  - JOURNAL ARTICLE
AU  - J M Henley
TI  - Epinephrine-stimulated maintained rubidium efflux from guinea pig hepatocytes may involve alpha 1- and alpha 2-adrenoceptors.
DP  - 1985 Nov 01
TA  - Molecular Pharmacology
PG  - 431--435
VI  - 28
IP  - 5
4099  - http://molpharm.aspetjournals.org/content/28/5/431.short
4100  - http://molpharm.aspetjournals.org/content/28/5/431.full
SO  - Mol Pharmacol1985 Nov 01; 28
AB  - The epinephrine-stimulated maintained increase in 86Rb efflux from guinea pig hepatocytes may consist of both alpha 1- and alpha 2-adrenoceptor-mediated components. Both the alpha 1-selective adrenoceptor agonist phenylephrine and the alpha 2-selective agonist clonidine evoked a maintained increase in 86Rb efflux. Prazosin, an alpha 1-selective antagonist, did not inhibit the maintained increase in 86Rb efflux elicited by epinephrine, whereas yohimbine, an alpha 2-selective antagonist, did. In the absence of external Ca, no maintained increase in 86Rb efflux was observed. The results suggest that there may be two separate alpha-adrenergic sensitive Ca influx pathways into guinea pig hepatocytes, one mediated by alpha 1- and the other by alpha 2-adrenoceptor activation.