RT Journal Article
SR Electronic
T1 Epinephrine-stimulated maintained rubidium efflux from guinea pig hepatocytes may involve alpha 1- and alpha 2-adrenoceptors.
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 431
OP 435
VO 28
IS 5
A1 J M Henley
YR 1985
UL http://molpharm.aspetjournals.org/content/28/5/431.abstract
AB The epinephrine-stimulated maintained increase in 86Rb efflux from guinea pig hepatocytes may consist of both alpha 1- and alpha 2-adrenoceptor-mediated components. Both the alpha 1-selective adrenoceptor agonist phenylephrine and the alpha 2-selective agonist clonidine evoked a maintained increase in 86Rb efflux. Prazosin, an alpha 1-selective antagonist, did not inhibit the maintained increase in 86Rb efflux elicited by epinephrine, whereas yohimbine, an alpha 2-selective antagonist, did. In the absence of external Ca, no maintained increase in 86Rb efflux was observed. The results suggest that there may be two separate alpha-adrenergic sensitive Ca influx pathways into guinea pig hepatocytes, one mediated by alpha 1- and the other by alpha 2-adrenoceptor activation.