%0 Journal Article %A M Yamakawa %A K Ezumi %A M Shiro %A H Nakai %A S Kamata %A T Matsui %A N Haga %T Relationships of the molecular structure of aldosterone derivatives with their binding affinity for mineralocorticoid receptor. %D 1986 %J Molecular Pharmacology %P 585-589 %V 30 %N 6 %X The molecular structures of 19-nor-11-deoxycorticosterone (III) and 21-hydroxypregna-4,11-diene-3,20-dione (IV) were determined by X-ray crystallographic analysis and the factors affecting the binding affinities for the mineralocorticoid receptor were examined with six aldosterone derivatives (I-VI) containing these two compounds. The most important factor was found to be the steric one; affinity increased with increasing flatness of the structure. The electronic factor may be a minor influence although a good relationship was found between the affinity and the 13C-NMR chemical shift of the C(5) atom. The factor playing no role in the binding is the hydrophobic one. %U https://molpharm.aspetjournals.org/content/molpharm/30/6/585.full.pdf