RT Journal Article
SR Electronic
T1 Studies on the Noradrenaline α-Receptor
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 28
OP 36
VO 3
IS 1
A1 M. MAY
A1 J. F. MORAN
A1 H. KIMELBERG
A1 D. J. TRIGGLE
YR 1967
UL http://molpharm.aspetjournals.org/content/3/1/28.abstract
AB The rates of recovery of response of rabbit aortic strips, blocked with N,N-dimethyl-2-bromo-2-phenylethylamine, to noradrenaline, adrenaline, N-ethyl- and N-isopropyl-noradrenaline have been determined. The close similarities of these recovery rates suggests that "spare" receptors are of little significance in this system. The use of 3H-labeled N,N-dimethyl-2-bromo-2-phenylethylamine enabled an estimate of the concentration of α-receptors, 1.15 x 1012 receptors per milligram of tissue dry weight, to be made and also provided good evidence for the view that tissue response is proportional to the concentration of agonist-receptor complex. ACKNOWLEDGMENTS The authors wish to acknowledge the assistance of Miss Marlene Calderone. This investigation was supported by a grant from the National Institute of Health, U. S. Public Health Service (GM 11603).