PT  - JOURNAL ARTICLE
AU  - MANFRED KIESE
TI  - Reactions of <em>N,N</em>-Dimethylaniline-<em>N</em>-oxide with Hemoglobin
DP  - 1967 Jan 01
TA  - Molecular Pharmacology
PG  - 9--14
VI  - 3
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/3/1/9.short
4100  - http://molpharm.aspetjournals.org/content/3/1/9.full
SO  - Mol Pharmacol1967 Jan 01; 3
AB  - N,N-Dimethylaniline-N-oxide reduces ferrihemoglobin (methemoglobin) under anaerobic conditions. In solutions of hemoglobin and N,N-dimethylaniline-N-oxide under air ferrihemoglobin is formed. Oxygen is necessary for this reaction. After a short lag phase the reaction rapidly increases in rate. Partial oxidation of the hemoglobin accelerates the reaction. Reagents which react with —SH groups also accelerate thue reaction. However, the "autocatalytic" course is retained after the —SH groups are blocked. ACKNOWLEDGMENT The author is grateful to Miss Maria Arnold and Miss Luise Richter for competent technical assistance.