TY - JOUR T1 - Reactions of <em>N,N</em>-Dimethylaniline-<em>N</em>-oxide with Hemoglobin JF - Molecular Pharmacology JO - Mol Pharmacol SP - 9 LP - 14 VL - 3 IS - 1 AU - MANFRED KIESE Y1 - 1967/01/01 UR - http://molpharm.aspetjournals.org/content/3/1/9.abstract N2 - N,N-Dimethylaniline-N-oxide reduces ferrihemoglobin (methemoglobin) under anaerobic conditions. In solutions of hemoglobin and N,N-dimethylaniline-N-oxide under air ferrihemoglobin is formed. Oxygen is necessary for this reaction. After a short lag phase the reaction rapidly increases in rate. Partial oxidation of the hemoglobin accelerates the reaction. Reagents which react with —SH groups also accelerate thue reaction. However, the "autocatalytic" course is retained after the —SH groups are blocked. ACKNOWLEDGMENT The author is grateful to Miss Maria Arnold and Miss Luise Richter for competent technical assistance. ER -