RT Journal Article
SR Electronic
T1 Estimation of the Turnover Rate of Barbiturate Side-Chain Oxidation Enzyme in Rat Liver
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 216
OP 218
VO 3
IS 2
A1 IRWIN M. ARIAS
A1 ANTONIO DE LEON
YR 1967
UL http://molpharm.aspetjournals.org/content/3/2/216.abstract
AB Hepatic side-chain oxidation of hexobarbital was estimated in rats before, during, and after administration of sodium phenobarbital in increasing dosage for 1 to 84 days. The half-life of the enzyme was virtually the same during and after drug administration. These results indicate that phenobarbital increases synthesis of the enzyme, and they illustrate the estimation of enzyme degradation by analysis of the change in enzyme level from one steady state to another. This work was supported by Research Grants from time United States Public Health Service (AM-02019 and HD-00674).