PT  - JOURNAL ARTICLE
AU  - M. ENTMAN
AU  - R. BRESSLER
TI  - The Mechanism of Action of Hypoglycin on Long-Chain Fatty Acid Oxidation
DP  - 1967 Jul 01
TA  - Molecular Pharmacology
PG  - 333--340
VI  - 3
IP  - 4
4099  - http://molpharm.aspetjournals.org/content/3/4/333.short
4100  - http://molpharm.aspetjournals.org/content/3/4/333.full
SO  - Mol Pharmacol1967 Jul 01; 3
AB  - Intravenous administration of hypoglycin (L-α-amino-β-methylenecyclopropanepropionic acid) to mice resulted in hypoglycemia, which was preceded by a decrease in palmitate oxidation by myocardial homogenates from treated animals. The homogenates from treated animals carried out normal rates of glucose and hexanoate oxidation, but demonstrated depressed levels of palmityl-CoA:carnitine acyltransferase activity. The addition of carnitine to the myocardial homogenates restored both the depressed palmitate oxidation and palmityl-CoA:carnitine acyltransferase activity to normal levels. The administration of carnitine to hypoglycin-treated animals prevented the decreases in myocardial palmitate oxidation, palmityl-CoA:carnitine acyltransferase activity, and the hypoglycemia. ACKNOWLEDGMENT We wish to thank Dr. H. Lebovitz for his help and advice. Supported by U.S.P.H.S. Grants no. HE 7061 and 5TIGM-516.