RT Journal Article
SR Electronic
T1 The Mechanism of Action of Hypoglycin on Long-Chain Fatty Acid Oxidation
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 333
OP 340
VO 3
IS 4
A1 M. ENTMAN
A1 R. BRESSLER
YR 1967
UL http://molpharm.aspetjournals.org/content/3/4/333.abstract
AB Intravenous administration of hypoglycin (L-α-amino-β-methylenecyclopropanepropionic acid) to mice resulted in hypoglycemia, which was preceded by a decrease in palmitate oxidation by myocardial homogenates from treated animals. The homogenates from treated animals carried out normal rates of glucose and hexanoate oxidation, but demonstrated depressed levels of palmityl-CoA:carnitine acyltransferase activity. The addition of carnitine to the myocardial homogenates restored both the depressed palmitate oxidation and palmityl-CoA:carnitine acyltransferase activity to normal levels. The administration of carnitine to hypoglycin-treated animals prevented the decreases in myocardial palmitate oxidation, palmityl-CoA:carnitine acyltransferase activity, and the hypoglycemia. ACKNOWLEDGMENT We wish to thank Dr. H. Lebovitz for his help and advice. Supported by U.S.P.H.S. Grants no. HE 7061 and 5TIGM-516.