RT Journal Article
SR Electronic
T1 The Effect of Reduced and Oxidized Pteridine on Dopamine-β-Hydroxylase Activity
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 396
OP 398
VO 3
IS 4
A1 MENEK GOLDSTEIN
A1 TONG HYUB JOH
YR 1967
UL http://molpharm.aspetjournals.org/content/3/4/396.abstract
AB Tetrahydropteridine (DMPH4) reacts with dopamine-β-hydroxylase anaerobically and forms a reduced enzyme intermediate which aerobically catalyzes the β-hydroxylation of tyramine-3H. Under aerobic conditions DMPH4, in combination with NADH, is effective in the stimulation of enzymic β-hydroxylation. Oxidized DMPH4 inhibits the enzymic activity.