TY - JOUR T1 - The Effect of Reduced and Oxidized Pteridine on Dopamine-β-Hydroxylase Activity JF - Molecular Pharmacology JO - Mol Pharmacol SP - 396 LP - 398 VL - 3 IS - 4 AU - MENEK GOLDSTEIN AU - TONG HYUB JOH Y1 - 1967/07/01 UR - http://molpharm.aspetjournals.org/content/3/4/396.abstract N2 - Tetrahydropteridine (DMPH4) reacts with dopamine-β-hydroxylase anaerobically and forms a reduced enzyme intermediate which aerobically catalyzes the β-hydroxylation of tyramine-3H. Under aerobic conditions DMPH4, in combination with NADH, is effective in the stimulation of enzymic β-hydroxylation. Oxidized DMPH4 inhibits the enzymic activity. ER -