RT Journal Article
SR Electronic
T1 Multiple opioid receptors: ligand selectivity profiles and binding site signatures.
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 265
OP 272
VO 36
IS 2
A1 Goldstein, A
A1 Naidu, A
YR 1989
UL http://molpharm.aspetjournals.org/content/36/2/265.abstract
AB Methods are described for studying mu, delta, and kappa opioid binding sites, each without interference from the others. A large array of ligands has been characterized by ligand selectivity profiles, graphic depictions of affinities and selectivities. Binding site signatures have been derived, which uniquely describe each of the three types of sites. The mu, delta, and kappa binding sites have interesting common features and distinctive differences.