PT  - JOURNAL ARTICLE
AU  - S Westin
AU  - A Ström
AU  - J A Gustafsson
AU  - P G Zaphiropoulos
TI  - Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression.
DP  - 1990 Aug 01
TA  - Molecular Pharmacology
PG  - 192--197
VI  - 38
IP  - 2
4099  - http://molpharm.aspetjournals.org/content/38/2/192.short
4100  - http://molpharm.aspetjournals.org/content/38/2/192.full
SO  - Mol Pharmacol1990 Aug 01; 38
AB  - The effects of growth hormone (GH) on two constitutively expressed rat liver cytochrome P-450 (P-450) enzymes, namely P-450f (IIC7) and P-450PB1 (IIC6), have been investigated. Hypophysectomy of both male and female rats results in low expression of P-450f. Single daily injections of GH cannot restore expression of P-450f but further repress it. Continuous administration of GH, on the other hand, increases expression of P-450f to levels comparable to those of the normal male and female rat. P-450PB1 is minimally affected by hypophysectomy or GH treatment, although a weak but significant repression by continuous administration of GH can be detected. Run-on analysis shows that continuous GH treatment increases transcription of P-450f. In addition, the sequence of the 5' flanking region of this gene reveals DNA segments that might have a putative role in the transcriptional regulation of P-450f by GH.