PT  - JOURNAL ARTICLE
AU  - D De Prost
AU  - V Ollivier
AU  - J Hakim
TI  - Pentoxifylline inhibition of procoagulant activity generated by activated mononuclear phagocytes.
DP  - 1990 Oct 01
TA  - Molecular Pharmacology
PG  - 562--566
VI  - 38
IP  - 4
4099  - http://molpharm.aspetjournals.org/content/38/4/562.short
4100  - http://molpharm.aspetjournals.org/content/38/4/562.full
SO  - Mol Pharmacol1990 Oct 01; 38
AB  - When appropriately stimulated, monocytes are able to initiate blood coagulation through the membrane expression of tissue factor. This procoagulant activity is thought to play a role in activating coagulation in response to inflammatory stimuli in vivo. We found that pentoxifylline, a methylxanthine derivative already reported to regulate some monocyte functions, inhibits the procoagulant activity developed by U937 cells and monocytes in vitro in response to endotoxin. This effect was accompanied by an early increase in intracellular levels of cyclic AMP and was mimicked by compounds that induce an increase in the level of cyclic AMP levels. These results suggest that the suppressive effect of pentoxifylline occurs at least in part via an increase in intracellular cyclic AMP levels.