PT  - JOURNAL ARTICLE
AU  - Balzarini, J
AU  - Bernaerts, R
AU  - Verbruggen, A
AU  - De Clercq, E
TI  - Role of the incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine and its carbocyclic analogue into DNA of herpes simplex virus type 1-infected cells in the antiviral effects of these compounds.
DP  - 1990 Mar 01
TA  - Molecular Pharmacology
PG  - 402--407
VI  - 37
IP  - 3
4099  - http://molpharm.aspetjournals.org/content/37/3/402.short
4100  - http://molpharm.aspetjournals.org/content/37/3/402.full
SO  - Mol Pharmacol1990 Mar 01; 37
AB  - The carbocyclic analogue of (E)-5-(2-iodovinyl)-2'-deoxyuridine (C-IVDU) is, like its parent compound (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU), a potent and selective inhibitor of herpes simplex virus type 1 (HSV-1). There is a close correlation between the inhibition of viral DNA synthesis and the antiviral activity of both IVDU and C-IVDU. IVDU and C-IVDU inhibit viral DNA synthesis at 0.2 and 0.5 microM, respectively, and interfere with cellular DNA synthesis at concentrations that are 10- to 40-fold in excess of their antivirally effective doses. At concentrations affording a similar antiviral effect, C-[125I]IVDU is incorporated into viral and cellular DNA of HSV-1-infected Vero cells to a 7- to 10-fold lesser extent than IVDU. [125I]IVDU but not C-[125I]IVDU leads to breakage of both DNA strands when incorporated into HSV-1 DNA.