RT Journal Article
SR Electronic
T1 Stimulation of adenylate cyclase by amylin in CHO-K1 cells.
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 894
OP 899
VO 41
IS 5
A1 C S D'Santos
A1 A Gatti
A1 D R Poyner
A1 M R Hanley
YR 1992
UL http://molpharm.aspetjournals.org/content/41/5/894.abstract
AB The CHO-K1 cell line responds to the peptide amylin by a rapid elevation of cAMP. The related peptide calcitonin gene-related peptide (CGRP) is 100 times less potent at stimulating adenylate cyclase than is amylin. The actions of amylin at this receptor are concentration dependent and not antagonized by the CGRP antagonist CGRP-(8-37). Although these cells have receptors for calcitonin, amylin is unable to take part in any high affinity interaction with these receptors, as assessed by radioligand binding. The CHO-K1 cell line has receptors for amylin that are distinct from those for calcitonin and CGRP.